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REGENFAST® is het eerste product binnen de tandheelkunde dat polynucleotiden (PN), hyaluronzuur (HA) en mannitol combineert en daarmee het biologisch potentieel van deze werkzame stoffen volledig benut. Het stimuleert diverse weefselcellen welke belangrijk zijn voor de regeneratieprocessen van hard- en zacht weefsel.18
Gebaseerd op ervaringen uit verschillende medische vakgebieden (dermatologie, esthetische geneeskunde en algemene wondheelkunde), dienen zich in de tandheelkunde vele indicatiegebieden aan, waarbij de positieve effecten van de combinatie van hyaluronzuur en polynuceotiden gunstig blijken voor de regeneratieve processen.
Alle bestanddelen van REGENFAST® zijn biocompatibel en volledig resorbeerbaar.
Referenties
1. Mendoza, Gracia et al. “Inhibitory effects of different antioxidants on hyaluronan depolymerization.” Carbohydrate research vol. 342,1 (2007): 96-102.
2. Guizzadi, S et al. “Hyaluronate increases polynucleotides effect on human cultured fibroblasts.” Journal of Cosmetics, Dermatological Sciences and Applications 2013; 3: 124-128.
3. Sini, P et al. “Effect of polydeoxyribonucleotides on human fibroblasts in primary culture.” Cell biochemistry and function vol. 17,2 (1999): 107-14.
4. Cavallini, M et al. “Long Chain Polynucleotides Gel and Skin Biorevitalization.” International Journal of Plastic Dermatology-ISPLAD. 2007; 3(3): 27-32.
5. Stanghellini, E et al. Evaluation of antioxidant activity of a topical cream. Fifth International Workshop on Photodermatology. 30-31/05/2003.
6. Neunzehn, J et al. “Eggshells as natural calcium carbonate source in combination with hyaluronan as beneficial additives for bone graft materials, an in vitro study.” Head & face medicine vol. 11 12. 16 Apr. 2015.
7. Greco, R M et al. “Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix.” Journal of cellular physiology vol. 177,3 (1998): 465-73.
8. King, S R et al. “Beneficial actions of exogenous hyaluronic acid on wound healing.” Surgery vol. 109,1 (1991): 76-84.
9. Stern, R et al. “Hyaluronan fragments: an information-rich system.” European journal of cell biology vol. 85,8 (2006): 699-715.
10. Rooney, P et al. “Angiogenic oligosaccharides of hyaluronan enhance the production of collagens by endothelial cells.” Journal of cell science vol. 105 ( Pt 1) (1993): 213-8.
11. Sattar, A et al. “Application of angiogenic oligosaccharides of hyaluronan increases blood vessel numbers in rat skin.” The Journal of investigative dermatology vol. 103,4 (1994): 576-9.
12. Neunzehn, J „Entwicklung eines bioinspirierten Knochenregenerationsmaterials auf Basis von Putamen Ovi und Hyaluronsäure“ Dresden, Techn. Univ., Diss., 2012.
13. Colangelo, M T et al. “Polynucleotide biogel enhances tissue repair, matrix deposition and organization.” Journal of biological regulators and homeostatic agents vol. 35,1 (2021): 355-362.
14. Colangelo M.T. et al., Applied Sciences. 2021; 11(10):4405.
15. De Caridi, G et al. “Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study.” International wound journal vol. 13,5 (2016): 754-8.
16. Stagni, C et al. “Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up.” BMC musculoskeletal disorders vol. 22,1 773. 12 Sep. 2021.
17. Pilloni, A et al. “Clinical effects of the adjunctive use of polynucleotide and hyaluronic acid-based gel in the subgingival re-instrumentation of residual periodontal pockets: A randomized, split-mouth clinical trial.” Journal of periodontology, 10.1002/JPER.22-0225. 3 Oct. 2022.
18. MASTELLI srl, Italy. “REGENFAST® Sterile gel for dental use containing polynucleotides and hyaluronic acid 20 mg/ml.” IFU (10/2021).
Producent REGENFAST®: Mastelli srl Via Bussana Vecchia 32 18038 Sanremo (IM), Italie
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